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BPC-157 reportedly induced increased levels of phosphorylation of both PAK and paxillin, while the total protein level remained unchanged

Proteolytic digestion ensures that only stable covalent adducts are detected but these harsh conditions also have a drawback: incompatibility with sensitive/labile functional groups

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In conclusion, IA DDSs have the potential to enhance the penetration of drugs into the cartilage extracellular matrix, facilitating the sustained release of the potential peptides in vivo