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There are various possible causes: Noise, acoustic trauma emotional strain (stress, burnout, overwork, anxiety) blockage of the auditory canal with ear wax or a foreign object such as a cotton bud chronic middle ear infection burst ear drum Otosclerosis: A bone disease located in the middle ear Menire's disease: Sudden attacks of vertigo (dizziness) Age-related hardness of hearing Circulation problems Jaw muscle or jaw joint complaints Changes or blockages in the cervical spine non-malignant tumors affecting the auditory nerve (vestibular schwannoma) Additionally, tinnitus can stem from: High blood pressure (hypertension), low blood pressure (hypotension), cardiovascular disease (arrhythmia, arteriosclerosis), and metabolic diseases (diabetes mellitus), and hypo- or hyperthyroidism, elevated blood fat levels, anemia, a traumatic brain injury or anesthetics

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Another layer of complexity involves the precise regulation of TrkB receptor trafficking and signaling termination

Gender differences in moderate drinking effects

2021a;41:73950