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Apart from clinical efficacy defined as the change in Hamilton Depression Rating Scale (HAMD)-17 score, secondary outcomes include changes in pathophysiological mechanisms related to depression as well as changes in local brain activity (functional Magnetic Resonance Imaging, fMRI) and white matter integrity (Diffusion Tensor Imaging, DTI)

Storage: Lyophilized: freeze at 20 C (4 F) for up to 12 months

Oxeiptosisa cell death pathway to mitigate damage caused by radicals

Done by Winther K.H

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Among the MEL metabolites, AMK is particularly active against reactive nitrogen species