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The mechanism underlying these opposing gastrointestinal effects likely relates to semaglutides complex effects on gastrointestinal motility, with some patients experiencing accelerated intestinal transit while others experience overall slowing of gastrointestinal motility

Nov 15 2019;15(11):1561-1570

For people on GLP-1 therapy, glycine may help calm nausea, reduce bloating, and improve digestive comfort

Ann N Y Acad Sci 2004;1033:42-51

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Some GLP-1s are produced in auto-inject pens, which are costlyand furthermore, have contributed to the shortage of these medications, as the auto-inject pen manufacturers cannot keep up with the demand for the drug