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However, the enzymatic activity and transcript abundance of glutathione reductases, which convert GSSG back to GSH, did not change

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Clinical application of anticancer agents has been often hampered by toxicity against normal cells, so the achievement of their cancer-specific action is still one of the major challenges to be addressed

In skin biology, theres interest in glutathione because of its proposed roles in: Inhibiting tyrosinase (an enzyme crucial to melanin production) in theory reducing pigment formation

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Studies have highlighted the role of dietary intake in mitigating glutathione reductase deficiency, underlining the crucial relationship between nutrition and enzyme activity