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New York: Thieme Publishers

The NNMT-blocking mechanism of 5-amino-1MQ has been shown to increase levels of the cofactor NAD+, whose replenishment in organisms promotes muscular, cognitive, and immune function, as well as increased lifespan [4, 5]

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Because neither compound is licensed in the UK, no formal pharmacokinetic or pharmacodynamic interaction studies have been conducted or reviewed by the MHRA

The original genetic-validation study used antisense oligonucleotide-mediated knockdown of NNMT in adipose tissue of mice on a high-fat diet, with whole-body and adipose-tissue metabolic endpoints measured against scrambled-oligonucleotide controls [2]