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Androgen regulation is a very important point, but since the major prostate cancer cell lines used in the present study were not responsive to hormone levels, we did not assess changes in angiogenesis due to androgen administration

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Statements Author contributions MoA: Validation, Data curation, Conceptualization, Methodology, Writing review & editing, Investigation, Writing original draft

In vitro , it has been demonstrated that insulin inhibits hepatic SHBG synthesis (59)

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