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Pitout, J
doi: 10.1016/j.bbamcr.2009.01.006
HZ, C-EY, TL, and M-XZ: literature search
Osbourne and Sattely first identified the three enzymes conserved in many limonoid-producing plants that are involved in the transformation of 334 to a protoliminoid precursor, melianol ( 335 )
Taking into account that TNF and ROS may induce NF- B-dependent gene transcription, this potentially results in an amplification loop of TNF and ROS signaling [269]
In addition, it altered the resorption markers, RANKL (receptor activator NF-kB), tartrate resistant acid phosphatase (TRAcP5b) and cathepsin K activity
