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Mechanisms by which metabolites of DCVC and other nephrotoxic haloalkene cysteine S -conjugates alter thiol status may involve direct inhibition of glutathione reductase (Lock and Schnellmann, 1990) and generation of oxidative stress that leads indirectly to oxidation of thiol compounds (Chen et al., 1990)

5i) and promoted the expression of these genes (Fig

Am J Physiol Lung Cell Mol Physiol 292 : L824L832 Lee KS, Kim SR, Park HS, Park SJ, Min KH, Lee KY, Choe YH, Hong SH, Han HJ, Lee YR, Kim JS, Atlas D, Lee YC 2007 A novel thiol compound, n-acetylcysteine amide, attenuates allergic airway disease by regulating activation of nf-kappab and hypoxia-inducible factor-1alpha

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