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doi: 10.1007/s00726-003-0011-2 72 YangMLDoyleHAClarkeSGHeroldKCMamulaMJ

R.1999Expression of UDPglucuronosyltransferases (UGTs) 2B7 and 1A6 in the human brain and identification of 5-hydroxytryptamine as a substrate.3651(May1999),156162,0003-9861 63

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32 The positive association between frequency of MTHFR -C677T and MTHFR -A1298C polymorphisms and latitude documented in the current study suggests that in areas closer to the equator, which are increasingly exposed to UVR, activity of the MTHFR enzyme reflects greater functional competency because of the absence of the MTHFR polymorphisms

Relationship between glutathione depletion, oxidative stress and disturbances in calcium homeostasis and energy metabolism