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e , Representative images (left panel) and quantification (right panel) of Wt1/p21 co-staining in ID8 Trp53 / omental tumours treated with cisplatin

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Moderate risk (high MRD after the first month of treatment, low MRD after the second cycle of chemotherapy)

Polyphenols: Curcumin, Resveratrol, EGCG, and Quercetin Curcumin , the active polyphenol in turmeric, inhibits NFB and PI3K/Akt/mTOR signaling, induces apoptosis and G2/M cellcycle arrest, and enhances natural killer (NK) cell cytotoxicity against breast cancer cells

Thus, p21-driven senescence is protective in acute settings but deleterious when persistent, underscoring its role as a context-dependent regulator rather than a simple tumor suppressor