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The OMM is permeable, mediates mitochondrial signal transmission, and carries molecules involved in fusion and fission, playing a crucial role in mitochondrial dynamics (Lin et al., 2022)

Complete nerve regeneration in severely affected individuals may take longer

Certain medical conditions and medications increase B12 requirements: Long-term use of metformin (diabetes medication) or proton pump inhibitors (PPIs for acid reflux) can impair B12 absorption [13] [14] Gastrointestinal conditions such as Crohn's disease, coeliac disease, or previous gastric surgery Autoimmune conditions beyond pernicious anaemia may affect B12 metabolism When to contact your GP : If you are taking B12 supplements or receiving injections but continue to experience symptoms, request a review

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Its chemical formula is based on the GIP amino acid sequence and its half-life of approximately 5 days is compatible with a once-weekly subcutaneous administration