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Furthermore, a study demonstrated that CIH can induce the upregulation of multiple pro-metastatic genes by activating the NF-B pathway in inflammatory breast cancer cells (Gutsche et al., 2016), highlighting the universal relevance of this mechanism across CIH-associated tumors

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Peak GH stimulation occurs within 40 to 60 minutes of injection, consistent with rapid plasma concentration peaks followed by GH secretory response [3]

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