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Notably, the study demonstrated that SARC patients with unmethylated MGMT had better PFS and a higher disease control rate compared to those with promoter hypermethylation [283]

Genetic testing is used to see if a person has the genetic variants that cause dEDS

In a similar manner, genetic deletion of the excitatory amino acid carrier type 1 (EAAC1), a glutamate transporter which also participates in the neuronal uptake of cysteine for GSH synthesis, significantly sensitized mice to TBI induced by controlled cortical impact, resulting in enhanced neuronal death and increased microglial activation (Aoyama et al., 2006

doi: 10.1177/030089167706300208

Perry DA, Amaranthus MP, Borchers JG, Borchers SL, Brainerd RE (1989) Bootstrapping in ecosystems

doi: 10.3390/ijms21176356