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Promotes normal deep sleep patterns: The pineal gland, which secretes melatonin, is responsible for sleep patterns

doi: 10.1016/j.cellsig.2025.111917 109 KadomotoSIzumiKMizokamiA

While the more obvious route would be directly suppressing TNF, that might not be a good idea because of its important roles in fighting infections and other invaders, which is already a concern for current treatments, they say

In Phase 2 trials, Ara-290 has been studied for small-fiber neuropathy in sarcoidosis, diabetic neuropathy and neuropathic pain, with reports of improved neuropathic symptom scores and corneal nerve-fiber measures [11]