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Stickel et al., 2000)
The deletion of Bhmt gene in mice resulted in an appreciable reduction in SAM/SAH ratio (i.e., the methylation potential) and a several-fold increase in hepatic and plasma total homocysteine (tHcy) concentrations (Teng et al., 2011)

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These supplements prevent plaque formation and have an anti-atherosclerotic impact by increasing cholesterol utilization and displaying anti-inflammatory qualities [242]

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The disease is the most common monogenic metabolic disorder globally