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EMT is observed in the process of renal interstitial, pulmonary and liver fibrosis [56,57,58,59], as well as in specific ocular tissue [32]

In fact, MOTS-c levels naturally rise during exercise, and giving MOTS-c to mice has been shown to enhance their physical performance (they can run longer on a treadmill)

Gonzlez-Fraguela ME, Hung ML, Vera H, Maragoto C, Noris E, Blanco L, Galvizu R, Robinson M (2013) Oxidative stress markers in children with autism spectrum disorders

By blocking System Xc or impeding the glutamate metabolic pathway, more ROS-induced lipid peroxidation and ferroptosis are triggered ( Erastin and RSL3 are two well-known compounds that induce ferroptosis ( via System Xc and to inhibit GPX4, respectively ( Figure 1 )

doi: 10.1016/j.freeradbiomed.2004.06.011

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