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Excessively low levels can cause a condition known as Laron Syndrome (dwarfism), which is usually diagnosed in childhood
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The neurotrophic agents capable of facilitating synaptogenesis and neurogenesis include nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3, and neurotrophin-4 [34,35]
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Their treatment is designed to correct the R83C mutation, the most common GSD1a disease-causing mutation
