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In addition, invertebrates models are genetically tractable and offer a powerful approach to dissect the core genetic underpinnings of SCZ, while vertebrate models, especially mammals, with their more complex nervous systems and behavioral repertoire, provide a closer approximation of the human condition to study SCZ-related traits

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Instead, here we show that genetic inhibition of different autophagy genes reduced H3K9 acetylation, which is sensitive to acetyl-CoA levels 50

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Some research suggests that chronic high-dose L-carnitine supplementation may increase TMAO levels via gut bacteria metabolism, and elevated TMAO has been associated with increased cardiovascular risk in observational studies