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In contrast, orally ingested l-arginine is subject to moderate-to-high rates of first-pass extraction both in intestine and liver, likely due to their high expression of arginase [32,33,34], increasing arginine catabolism and limiting systemic increases in circulating levels following its ingestion [8]

Conversely, the number of other PED samples increased (mean 21.1%) from 7.5% in 2020 to 32.9% in 2023

This selectivity reduces confounding variables in experimental designs focused on the somatotropic axis

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