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Accordingly, a Ca 2+ imaging study of the human submucosal plexus showed that under physiological conditions, communication from mast cells to nerves was rarely observed when mast cells were activated by IgE receptor crosslinking, which induces the release of a cocktail of mediators including proteases, histamine, and cytokines [122, 123]

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The PBAC independently reviews: The medicines clinical effectiveness how well it works compared to existing treatments Cost-effectiveness if the health benefits justify the cost The potential impact on the healthcare system and patients

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