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Salama SE, Eldeeb AE, Elbarbary AH, Abdelghany SE

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Excess glucose that cannot go through normal glycolysis engages in the polyol pathway where AR reduces glucose to sorbitol using NADPH as a cofactor, and SDH oxidizes sorbitol into fructose

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ET-1 also stimulates the formation of ROS through a mechanism dependent on ARG

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