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National Institutes of Health

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Flavonoid apigenin is an inhibitor of the NAD + ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome

Drug interactions: No known significant interactions

A nivel molecular, la reduccin de la actividad de NNMT modifica los patrones de metilacin celular, lo que puede alterar modificaciones epigenticas a travs de cambios en las proporciones SAM/S-adenosilhomocistena (SAH)

This distinction allows researchers to explore upstream metabolic regulation and cellular signaling mechanisms through a different experimental approach