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Experimental evidence has demonstrated that a decrease in ascorbic acid levels is tied to GSH depletion [12]

2.3.3.2 Triptolide Triptolide is extracted from the plant Tripterygium wilfordii , and studies have shown that it can reduce the protein level of mitochondrial hexokinase II, which blocks the translocation of BAD and BAX proteins to mitochondria and the activation of caspase 3, thus preventing the cleavage of GSDME and pyroptosis to eliminate head and neck cancer cells (Wang et al., 2023)

doi: 10.3109/02713688408997203

This observation suggests that glutathione redox potential could be one factor that determines some of the effects reported in glutathione-deficient mutants

10.1016/j.intimp.2020.106595 116 MirzadeganE.GolshahiH.SaffarianZ.DarziM.KhorasaniS.EdalatkhahH.et al (2022)

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