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MSM is likely safe to take by mouth for up to six months

[DOI] [PMC free article] [PubMed] [Google Scholar] Makris EA, MacBarb RF, Responte DJ, Hu JC, Athanasiou KA (2013) A copper sulfate and hydroxylysine treatment regimen for enhancing collagen cross-linking and biomechanical properties in engineered neocartilage

Gene expression profiling studies, particularly the Broad Institute Connectivity Map analysis published by Pickart and colleagues, demonstrated that GHK-Cu modulates the expression of approximately 4,000 human genes, representing roughly 6% of the human genome

Similarly, the reductions in the GSH/GSSG ratio and the relative protein expression levels of GPX4 and SLC7A11 caused by MALAT1 knockdown in KGN cells were restored by downregulation of miR-155-5p (Figure 8BE)

Overall, these results encourage larger randomized and controlled clinical trials on this topic

doi: 10.1016/j.neurobiolaging.2007.04.013 276 PetersA.VerderosaA.SetharesC