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also has an endothelium-dependent vasodilator effect involving the PI3-kinase/Akt pathway and subsequent NO release (122) and an endothelium-independent effect via the inhibition of Ca 2+ -channels and the Ca 2+ calmodulin complex and activation of potassium channels

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Arrestin-dependent but G-protein coupled receptor kinase-independent uncoupling of D2-dopamine receptors

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