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Respective primary antibodies were purchased from Cell Signaling Technology, except for anti-phospho-SMAD3 (Abcam, Cambridge, UK), anti-Ki67 (MIB-1

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Hyperhomocysteinemia decreases GSH peroxidase activity leading to the prevalence of GSSG on GSH with the GSH/GSSG impaired ratio causing some common cardiovascular and neurodegenerative disorders (159)

Skin conductance was measured with a 0.5 V constant voltage (EDA100C, Biopac Systems)