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Description
doi: 10.1038/s41598-023-29731-5, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 87

Moonlighting functions Many of the proteins involved in the ascorbateglutathione cycle reside in different intracellular compartments where they can have moonlighting as well as enzymatic functions

The integration of ferroptosis with immune checkpoint inhibition and conventional modalities such as radiotherapy and chemotherapy demonstrated synergistic sensitization of tumor cells while enhancing antitumor immune responses
Ferroptosis in cancers Ferroptosis and the epithelial-mesenchymal transition In vertebrates, the two basic cell types are epithelial cells and mesenchymal cells, which can transform into one another through a reversible process known as epithelialmesenchymal transition (EMT)

[8] Substrates [edit] While CROT's canonical substrate is octanoyl-CoA, CROT is also known to be able to catalyze the deacylation of numerous acyl-CoAs, such as acetyl-CoA, propionyl-CoA, butyryl-CoA, and hexanoyl-CoA

To date, the most well-studied PCD includes apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy, among others [11]
