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These free radicals can be neutralized by antioxidants

NLRP3 inflammasome is formed due to hyperglycaemia and hyperlipidaemia, which promote pro-inflammatory cytokines by upregulating IL-1, IL-6 and IL-18, leading towards exacerbation of DCM pathology (134)

[Google Scholar] Trakulsrichai S, Sathirakul K, Auparakkitanon S, Krongvorakul J, Sueajai J, Noumjad N, Sukasem C, Wananukul W (2015) Pharmacokinetics of mitragynine in man