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Data collection carried out in the Brigham and Women's Hospital Center for Clinical Investigation (formally supported by NIH Grant M01 RR02635 currently part of Harvard Clinical and Translational Science Center supported by NIH UL1 RR025758)

Complete supply calculation for a 16-week protocol Weeks 1-4 (2mg/week): 2mg x 4 weeks = 8mg total Weeks 5-8 (4mg/week): 4mg x 4 weeks = 16mg total Weeks 9-12 (8mg/week): 8mg x 4 weeks = 32mg total Weeks 13-16 (12mg/week): 12mg x 4 weeks = 48mg total Grand total: 104mg over 16 weeks Now translate that into vials: Using 10mg vials exclusively: 104mg / 10mg = 10.4 vials

10.1016/j.ecoenv.2019.109425 64 DingZ.WuX.WangY.JiS.ZhangW.KangJ.et al (2020)

Pollution causes depletion of skin surface antioxidant Vitamin E Vitamin E is the main antioxidant present at the surface of the skin that protects it from the damaging effect of free radicals

Clinical data regarding OM and dietary intake were collected at the same time points as the saliva samples (pre-RT, mid-RT, and final-RT) from patient records