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However, certain populations are at higher risk of deficiency, including older adults, vegans and vegetarians, individuals with malabsorption disorders (such as pernicious anaemia or coeliac disease), and those taking long-term proton pump inhibitors or metformin

The risk of anemia is also higher in these patients but appears to be independent of vitamin B12 status

Mechanistic biochemical studies

doi: 10.26402/jpp.2024.1.09

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Others benefit from repeated cycles for chronic or complex issues
