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treatment continued until disease progression or intolerable toxicity

( Collagenase VII-Induced Intracerebral Hemorrhage Model Intracerebral hemorrhage was induced via stereotactic administration of 0.25 U/l bacterial collagenase type VII (Sigma, United States), as Rosenberg described ( Brain Water Content Rats were anesthetized, and the brains were collected 3 days following ICH

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In patients with creatinine clearances between 45 mL/min and 79 mL/min, modify administration of ibuprofen as follows [see Warnings and Precautions (5.6), Drug Interactions (7) and Clinical Pharmacology (12.3)] : Obtain complete blood count on Days 1, 8, and 15 of each cycle

Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 2005, 1754(12): 253262

Third, and perhaps most importantly, self-administration removes the clinical feedback loop