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Chemical Properties Mechanisms Investigated in Preclinical Research L-Carnitine CPT-1/OCTN2 Long-Chain Fatty Acid Mitochondrial Transport: L-Carnitine is observed in preclinical models to function as an obligate co-substrate for carnitine palmitoyltransferase-1 (CPT-1), the rate-limiting enzyme at the outer mitochondrial membrane that transfers long-chain acyl groups from acyl-CoA to carnitine to form acylcarnitine

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In contrast, the transport of glycolytic substrates such as lactate from oligodendrocytes to neurons is found to be disrupted in SOD1 G93A mice spinal cord (Lee et al., 2012