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These parameters were also measured at the end-of-trial visit at week 111 (within 5 days either side of scheduled visit day)

Vitamin B12 deficiency symptoms The most common vitamin B12 deficiency symptoms include (2, 11): Pale skin Low energy Shortness of breath Palpitations Tingling or numbness in hands and/or feet Lower sense of position of body parts Lower ability to feel vibrations Abnormal walking pattern Muscle weakness Loss of concentration Poor memory Confusion Depression Vision problems Insomnia Impotency Poor bowel or bladder control Constipation Flatulence Sore tongue Appetite loss Loss of mental or physical drive Can I have a vitamin B12 deficiency without any symptoms

Sanz-Cuesta T, Escortell-Mayor E, Cura-Gonzalez I et al (2020) Oral versus intramuscular administration of vitamin B12 for vitamin B12 deficiency in primary care: a pragmatic, randomized, non-inferiority clinical trial (OB12)

In the SELECT trial, patients did not enroll for the specific purpose of weight loss and received standard of care covering management of CV risk factors, including medical treatment and healthy lifestyle counseling, but without a specific focus on weight loss