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454 Moreover, centrally mediated factors, such as cognitive processes (e.g., attention, distraction, catastrophizing), contextual beliefs about pain, and emotional states (e.g., depression, anxiety), significantly influence the pain experience

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Acknowledgements The authors are thankful to the Riphah Institute of Pharmaceutical Sciences, Riphah International University and Department of Pharmacy, Iqra university Islamabad, for helping in this research work

403 Using an exploratory "cognitive age" calculation, Magtein was associated with an estimated 7.5-year reduction in brain age relative to the placebo group

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