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10.1016/j.conb.2007.01.009 [DOI] [PubMed] [Google Scholar] Gherardi E., Sandin S., Petoukhov M

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7 th ed

World Obesity Atlas 2025

Pain Modulation Research DSIP demonstrates analgesic properties in experimental pain models: Acute Pain Models: Investigation using thermal, mechanical, and chemical nociception tests Chronic Pain Research: Studies in neuropathic pain, inflammatory pain, and chronic pain models Opioid System Interactions: Research on endogenous opioid pathway modulation Central Pain Processing: Investigation of spinal and supraspinal analgesic mechanisms Tolerance and Dependence: Studies examining whether DSIP produces tolerance or dependence Research protocols employ various pain assessment methods (tail-flick, hot plate, von Frey filaments, formalin test) combined with molecular analysis to characterize DSIPs analgesic mechanisms

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