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Clinical experience from thousands of patients in optimization medicine practices supports its use, but the formal evidence lags behind the clinical adoption

7 Treatment with antidepressant drugs increases hippocampal neurogenesis, and it has been hypothesized that increasing adult hippocampal neurogenesis may be a new drug target or mechanism for future antidepressant drugs

When downtime is reduced, training frequency and output can be maintained more consistently, supporting progressive overload and strength adaptation