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Transformative impact of nanocarrier-mediated drug delivery: overcoming biological barriers and expanding therapeutic horizons

Furthermore, we discuss potential therapeutic strategies designed to mitigate oxidative damage and prevent BBB disruption in neurodegenerative diseases, emphasizing the critical role of BBB protection in preventing further neuronal injury and slowing the progression of these brain disorders

Blood 109 , 32533259 (2007)

[DOI] [PMC free article] [PubMed] [Google Scholar] 154.Selhub J., Rosenberg I.H

In addition, we observe higher levels of malondialdehyde (MDA), protein carbonyls and 8-hydroguanosine (8-OHdG) DNA adduct, as hallmarks of cellular lipid, protein and DNA oxidative damage, respectively

Thus, the two compounds have varying mechanisms and effects