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In addition, activation of the HPA axis can create a feedback loop that perpetuates neuroinflammation

That is weak for indexing, because Google then sees multiple filter states without clear unique value

Increases in proinflammatory cytokine such as TNF, IL-4, IL-6 and IL-13 have all been shown to increase epithelial permeability and have been tied to increased expression of claudin-2 in animal and human models as well as decreased expression of JAM-A and occludin [152, 153]

Schuller, M

doi: 10.4049/jimmunol.1101186

Nucleus 9 , 216226 (2018)
