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doi: 10.3389/fncel.2025.1512591 Received 16 October 2024 Accepted 29 January 2025 Published 12 February 2025 Volume 19 - 2025 Edited by Donato Zipeto, University of Verona, Italy Reviewed by Pablo Trindade, Federal University of Rio de Janeiro, Brazil Mingzi Zhang, University of Southern California, United States Updates Copyright 2025 Goshi, Lam, Bogguri, George, Sebastian, Cadena, Leon, Hum, Weilhammer, Fischer and Enright
Chronic hypoxia for 7 or 14 d, but not 1 or 3 d, resulted in alpha-synuclein hyperphosphorylation at serine129 (-Syn p-S129) and protein aggregation, hippocampal neurodegeneration, and cognitive deficits, whereas the latter could be prevented by alpha-synuclein knockdown or an administered short peptide competing at -Syn S129

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The AFF 1 peptide, 8 residues in length, was then studied further as this specifically induced a response to human S

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