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An Essential Role for the K+-dependent Na+/Ca2+-exchanger, NCKX4, in Melanocortin-4-receptor-dependent Satiety

[DOI] [PubMed] [Google Scholar] 17.Cooper DE, Young PA, Klett EL, Coleman RA

The metabolic pathways of anthraquinones include mainly hydrolysis, glucuronidation, sulfation, methylation/demethylation, hydroxylation/dehydroxylation, oxidation/reduction, acetylation, and esterification, among which hydrolysis, glucuronidation, and sulfation are dominant ( Anthraquinones laxatives inhibit the absorption of water and sodium in the colon by inhibiting the activities of Na + -K + -ATPase of colonic epithelial cells (Figure 2)

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In about one-third of the analyzed cases, various arrhythmias were observed

The peptide sequence (residues 110128) was D-P-V-G-S-P-T-S-G-A-S-L-N-G-T-P-F-K-K-K, with an additional lysine added for charge