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doi: 10.1080/14737175.2021.1923479

Reviewing concurrent medications with a GP or pharmacist can identify potential contributors to cramping, particularly diuretics, SGLT2 inhibitors, and statins

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29,30 The oxygenation of C20-fatty acids from both 6 and 3 PUFAs produces a wide array of eicosanoid lipid mediators, including the well-studied prostaglandins (and their autoxidation analogues, the isoprostanes), thromboxanes, hydroxy-eicosatetraenoic acids (HETEs) and leukotrienes

Rosenbloom, A

However, the direct and powerful delivery method comes with increased risks: Skin Discoloration: Some individuals may develop a rash