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Most people get enough B6 in their diet, but if you are deficient in other B complex vitamins, such as folate and B12, youre more likely to be deficient in vitamin B6 as well ( Vitamin B6 deficiency is more common in people with liver, kidney, digestive or autoimmune diseases, as well as smokers, obese people, alcoholics and pregnant women ( In your body, B6 is involved in more than 150 enzyme reactions

[PubMed] [Google Scholar] 19.Lynch SR, Cook JD

Clinical studies have reported no harmful effects with chronic daily doses as high as 200 mg (many times the nutritional requirement), indicating a wide safety margin for this vitamin

Another factor, connecting the intestine to brain pathways, is severe stress

Conclusions We hypothesize that the high-folatelow vitamin B-12 interaction represents a novel cause of vitamin B-12 depletion caused by high folic-acid intake and consequent reduction in serum holoTC (Figure 11)

Most patients do well without sedation