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Conversely, anti-androgens reduce the synthesis of sebaceous lipids and improve acne, whereas androgen-insensitive subjects who lack functional androgen receptors do not produce sebum and do not develop acne

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In addition, hereditary bone mass abnormalities are associated with specific mutations in LRP5, Wnt5a, ROR2, and DVL1, and these abnormalities not only affect the skeletal system but also spread to other parts of the body (Table 2)

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J Immunol 194(6):29422953