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doi: 10.1080/07853890.2024.2307503

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Whilst mTORC1 activates S6 kinase, which phosphorylates serine residues on IRS which in turn uncouples IRS from the receptor and its substrates, mTORC2 can reactivate this signalling

If you have sub-optimal levels with symptoms, its worth a trial of B12 even if your serum B12 levels are normal

Its absence is a red flag

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