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I/R injury is related to the decrease of endogenous NAMPT and the down-regulated expression of SIRT1, SIRT3 and SIRT4

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We believe that our proposal to permit only the use of HCRIS data for purposes of the calculations required at proposed 411.363(c)(2) and (d)(2) while requiring comparisons only to hospitals that have a Medicare provider agreement with CMS strikes the appropriate balance between effectuating the intent of the statute and requiring strict compliance with the exact standards set forth in sections 1877(i)(3)(E)(ii) and (F)(ii) of the Act
