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Funding This work has been developed within the framework of the project eINS-Ecosystem of Innovation for Next Generation Sardinia (cod

Copper plays a role in multiple aspects of HIF-1 regulation, including the stabilization of HIF-1, formation of transcriptional complexes and binding to hypoxia-responsive element (HRE) sequences of target genes (50)

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All lymphocyte values were manually compared to the age-dependent reference values from Comans-Bitter et al

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