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Invading white blood cells secrete pro-inflammatory factors, which trigger reactive response of neural parenchymal cells, most notably reactive astrogliosis and microgliosis

Such behavioral deficits in A53T mice were accompanied by the presence of elevated -synuclein monomers and aggregates (Supplemental Figure 1J) and a remarkable loss of dopaminergic neurons in the substantia nigra, as indicated by tyrosine hydroxylase (TH) staining (Figure 1C)

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Puyo C, Kreig D, Saddi V, et al

Levels decline with age, contributing to: Slower recovery Reduced skin elasticity Increased oxidative stress
