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Notably, effects were achieved via multiple routes of application including intragastric and local, suggesting broad applicability across experimental delivery methods

Medical and Editorial Standards Medical review process: This article was reviewed for medical accuracy, scientific clarity, evidence alignment, and appropriate discussion of genetics, medications, supplements, biomarkers, and health-related claims

the reason for this is still unclear and likely involves complex biological and societal influences

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The entire analysis was performed using pyEMMA 66 freely available at github ( Reporting summary Further information on research design is available in the Nature Portfolio Reporting Summary linked to this article

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