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They are produced intracellularly in several stages: stages I and II include unmelanized immature premelanosomes in the middle of the melanocyte, whereas stages III and IV contain melanized melanosomes migrating to the outer edge of the cell through the dendrites 31

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Moreover, NADPH oxidase family members produce and in some cases H 2 O 2 , not only in activated macrophages and neutrophils but also in non-phagocytic cell types [6]